According to multiple sources, Indiana is the state with the most Powerball jackpot winners since 1992, with 39 wins. Missouri and Minnesota follow with 31 and 22 wins, respectively. Its important to note that not all states participate in the Powerball lottery, and some states have never sold a jackpot-winning ticket for either Powerball or Mega Millions. Additionally, some states have had more winners in other lottery games.