According to the search results, the state with the most murders varies depending on the source and the year. However, the states with the highest murder rates consistently include Louisiana, Missouri, South Carolina, Arkansas, Tennessee, Alaska, Maryland, Oklahoma, Mississippi, and North Carolina. The District of Columbia has the highest murder rate in the US, with a rate of 49.2 murders per 100,000 people. Mississippi had the highest murder rate in 2020, with 20.5 murders per 100,000 residents. Its important to note that crime rates can vary depending on factors such as population density, economic factors, and other state-specific population characteristics.