According to multiple sources, the state with the most Native Americans is not consistent. However, the states with the highest percentage of Native Americans in the U.S. are Alaska, Oklahoma, New Mexico, and South Dakota. Alaska has the highest share of the American Indian and Alaska Native population at 22%, followed by Oklahoma with 16% and New Mexico with 12% . Additionally, Alaska has the highest relative population of Native Americans, who make up 19.74% of the states total population, about 145,816 people. Oklahoma follows with 523,360 Native Americans (13.36%) and Arizona with 391,620 (5.64%) . It is important to note that the Native American population is honored every year on Native American Heritage Day, which is observed the Friday after Thanksgiving.