According to multiple sources, the state with the most Powerball jackpot winners is Indiana, with 39 wins since 1992. Other states that have had a significant number of Powerball jackpot winners include Missouri, Minnesota, Pennsylvania, and Wisconsin. Its important to note that not all states that participate in Powerball have had a jackpot winner, and some states have only had one or two jackpot winners since the games inception. Additionally, some states have had more Mega Millions jackpot winners than Powerball jackpot winners.