The ideal temperature for baking meatloaf is 350°F (175°C) . This temperature ensures that the meatloaf cooks evenly without drying out or burning on the outside. The cooking time for meatloaf can vary depending on several factors, such as the size of the loaf, the type of protein used, and the oven. As a general guideline, meatloaf cooked at 350°F usually takes around 35 to 45 minutes per pound of meatloaf. However, it is best to use a meat thermometer to check the internal temperature of the meatloaf to ensure that it is fully cooked and safe to eat. The internal temperature of meatloaf should reach around 160°F (71°C) . It is recommended to check the temperature of the meatloaf 10-15 minutes before the recipe says it will be done. Letting the meatloaf rest for 10 minutes after taking it out of the oven will help it hold its shape together.