The internal temperature of meatloaf should reach at least 160°F (71°C) before it is safe to eat, regardless of the type of meat used. It is important to use a meat thermometer to check the temperature of the meatloaf, as cooking times can vary depending on factors such as the oven model and the pan used. The oven temperature for cooking meatloaf is typically set at 350°F (175°C) . It is recommended to check the temperature of the meatloaf 10-15 minutes before the recipe says it will be done. If the meatloaf has not reached the desired temperature, it can be cooked longer, but it is not possible to undo an overcooked meatloaf. It is also recommended to let the meatloaf rest for 10 minutes after taking it out of the oven before slicing it.