If you have a burn blister, it is important not to burst it as this can lead to infection. Instead, keep the area clean and covered with a nonstick, sterile bandage. If the blister does break, gently clean the area with water and apply an antibiotic ointment. You can also apply a lotion or moisturizer to the area after the burn has cooled. It is important to avoid applying any creams or greasy substances to the area while it heals. Over-the-counter pain relievers such as acetaminophen or ibuprofen can help relieve pain and reduce inflammation. Seek medical attention if your burn is severe, if the blister is large, or if you think your burn is more severe.