Deion Sanders is facing serious health issues primarily related to diabetes and severe circulation problems in his left leg. His complications began after routine foot surgery to repair a dislocated toe, which led to severe blood clots in his femoral arteries. These clots caused poor blood circulation, resulting in compartment syndrome and tissue damage. Due to these complications, Sanders had two toes amputated in 2021 and has undergone around 10 surgeries on his left leg since then

. His condition involves chronic vascular disease with aneurysms and blood clots in his upper thigh, and he has persistent pain and neuropathy in his foot. Doctors have warned that if the blood flow problems are not addressed soon, Sanders may face further amputations, possibly even of his left foot. Currently, only one artery is supplying blood to his foot, down from the normal three, and he has lost feeling in the bottom of his foot

. Sanders also has a genetic predisposition to blood clots, with a family history that includes relatives who died from similar issues. This genetic factor likely worsened his condition

. In summary, Deion Sanders is battling diabetes-related complications that have caused severe blood clots and circulation problems, leading to multiple surgeries and amputations, with ongoing risks of further limb loss if not properly treated