The San Francisco 49ers' next game is tonight, Sunday, August 24, 2025, at 5:30 PM PT, against the Los Angeles Chargers in the preseason. Their regular season starts on Sunday, September 7, 2025, with an away game at the Seattle Seahawks, kickoff at 4:05 PM PT. Here are their upcoming preseason games for your reference:

• August 24, 2025, vs. Los Angeles Chargers at 5:30 PM PT
• Prior preseason games were August 9 vs. Denver Broncos and August 16 at Las Vegas Raiders

For the regular season, the first few games are:

• September 7 at Seattle Seahawks, 4:05 PM PT
• September 14 at New Orleans Saints, 1:00 PM PT
• September 21 vs Arizona Cardinals, 4:25 PM PT

Would you like the full schedule? This information is up to date as of now.