The Buffalo Bills will play their next game on August 23, 2025, in a preseason matchup against the Tampa Bay Buccaneers at 7:30 PM at Raymond James Stadium. Their regular season opener is on September 7, 2025, against the Baltimore Ravens at 8:20 PM at Highmark Stadium in Orchard Park. Here are the first few game dates and times for the Bills in the 2025 season:

• August 23, 2025, 7:30 PM (Preseason) at Tampa Bay Buccaneers
• September 7, 2025, 8:20 PM (Regular season Week 1) vs. Baltimore Ravens
• September 14, 2025, 1:00 PM (Week 2) at New York Jets
• September 18, 2025, 8:15 PM (Week 3) vs. Miami Dolphins

The Bills play mostly on Sunday afternoons or primetime slots like Sunday night and Thursday night during the season.