The season finale of NCIS Season 22 is scheduled to air on Monday, May 5, 2025. The episode is titled "Nexus" and will follow the team investigating a connection between mob boss Carla Marino and the Nexus cartel, involving a plot with stolen nuclear material. The finale will also explore key storylines including characters Parker and Lily, as well as an investigation by Agent Tim McGee into Deputy Director Gabriel LaRoche.