Thursday Night Football games in the 2025 NFL season typically kick off at 8:15 PM Eastern Time. The schedule started with Week 2 on Thursday, September 11, 2025, and continues every Thursday night through the season, with games such as:

• Week 3: Thursday, September 18, 2025 – Miami Dolphins at Buffalo Bills
• Week 4: Thursday, September 25, 2025 – Seattle Seahawks at Arizona Cardinals
• Week 5: Thursday, October 2, 2025 – San Francisco 49ers at Los Angeles Rams
• ... and continuing weekly on Thursdays until Week 17 on Thursday, December 25, 2025, with Denver Broncos at Kansas City Chiefs.

Pregame coverage starts at 7 PM ET on Prime Video, which exclusively streams the games in 2025. There is also a special Friday game on November 28, 2025, the day after Thanksgiving, known as Black Friday. In short, Thursday Night Football games in 2025 are every Thursday night at 8:15 PM ET on Prime Video, starting September 11 and continuing through December 25, including a Black Friday special game.