The best time to take Zoloft (sertraline) depends on how it affects each person. It is typically taken once daily, either in the morning or in the evening. If Zoloft causes drowsiness, taking it at bedtime may be preferable. Conversely, if it causes insomnia or trouble sleeping, taking it in the morning is usually better. The key is to take it consistently at the same time every day and not on an as-needed basis. Zoloft can be taken with or without food according to personal preference or tolerance. It may take several weeks to feel the full effect of the medication, and it is important to follow the doctor’s dosing instructions without abrupt changes or stopping without medical advice.