Lansoprazole should be taken about 30 minutes before a meal or snack, usually in the morning. This timing allows the medication to be absorbed better and work more effectively in reducing stomach acid, as food can interfere with its absorption. If prescribed twice daily, take one dose in the morning before breakfast and the second dose in the evening. Swallow the tablets or capsules whole with water or juice. If you have difficulty swallowing capsules, you can open them and mix the granules with water or soft food, but do not chew the granules. For people who experience nighttime symptoms, taking lansoprazole in the evening may be recommended by a doctor.