The best time to take magnesium glycinate is generally in the evening, about 1 to 2 hours before bedtime. This timing helps maximize its calming effects, promoting muscle relaxation and improved sleep quality due to the glycine content that enhances relaxation and reduces anxiety. Taking it before bed is especially useful if the goal is to support sleep and reduce nighttime restlessness. For other health goals like managing stress, anxiety, or muscle function during the day, magnesium glycinate can also be taken in the morning or afternoon as it provides calming effects without causing significant drowsiness. Consistency in the timing of magnesium intake is important to maintain stable magnesium levels and achieve long-term benefits. Taking magnesium glycinate with food can improve absorption and reduce the risk of digestive discomfort. If taking other medications, some may require separation in timing from magnesium to avoid interactions. In summary:

• For sleep and relaxation: Take magnesium glycinate 1-2 hours before bed.
• For daytime stress or muscle support: Take in the morning or early afternoon.
• Always aim for regular daily use and consider taking with food to minimize stomach upset.

This guidance aligns with the best practices for magnesium glycinate supplementation to optimize its calming and muscle-relaxing properties.