Joe Mixon is currently on the Houston Texans' Reserve/Non-Football Injury (NFI) list due to a foot/ankle injury sustained in the offseason. He will miss at least the first four games of the 2025 NFL season, making his earliest possible return Week 5 (October 5, 2025) against the Baltimore Ravens. However, given he has missed all offseason training and there has been no indication of practice or rehab progress, a return by Week 5 seems unlikely. The Texans have a bye in Week 6, so a more realistic earliest return could be Week 7 (October 19, 2025), depending on his progression. The team will evaluate his status after the first four games to make further determinations, and the timeline remains uncertain beyond that point.