Prostate cancer most commonly spreads (metastasizes) to the following locations:

• Bones : This is the most frequent site of prostate cancer spread, occurring in about 85% to 90% of metastatic cases. The cancer cells have a particular tendency to metastasize to the bone, although the exact reason is not fully understood

• Lymph nodes : Prostate cancer often first spreads to nearby lymph nodes, especially those in the pelvic area. It can then spread to distant lymph nodes elsewhere in the body

• Liver : The liver is another common site for prostate cancer metastases, though less frequent than bones and lymph nodes

• Lungs : Prostate cancer can also spread to the lungs, but this is less common than bone or lymph node involvement

• Other organs : Rarely, prostate cancer may spread to the brain, adrenal glands, pancreas, or other organs

Additionally, locally advanced prostate cancer can spread into tissues and organs near the prostate, such as the seminal vesicles, bladder, and rectum

. In summary, the primary sites where prostate cancer spreads are bones, lymph nodes, liver, and lungs, with bones being the predominant location by far