Neurotransmitter receptors are primarily found on the plasma membrane of the postsynaptic neuron, especially concentrated at the postsynaptic sites such as dendrites and the cell body. These receptors bind neurotransmitters released from the presynaptic neuron and can also be found in other regions of the neuron's membrane, including axons and sometimes presynaptic terminals. Their location on dendrites and the cell body allows them to detect chemical signals and initiate electrical responses in the postsynaptic neuron
. Summation in a neuron, which determines whether an action potential will be generated, takes place mainly at the axon hillock (also called the initial segment of the axon). This is where the neuron integrates all incoming excitatory and inhibitory postsynaptic potentials (EPSPs and IPSPs) from various inputs received on dendrites and the cell body. The axon hillock has a high density of voltage-gated sodium channels and acts as the decision point for firing an action potential based on the combined input signals
. Summary:
- Neurotransmitter receptors location: On the postsynaptic neuron's plasma membrane, especially on dendrites and the cell body, sometimes also on axons or presynaptic terminals
- Summation location: At the axon hillock (initial segment of the axon), where excitatory and inhibitory inputs are integrated to decide if an action potential will be triggered