Clemson University is located in Clemson, South Carolina, United States. The university's main campus covers about 1,400 acres in the foothills of the Blue Ridge Mountains and borders Lake Hartwell. Its address is 105 Sikes Hall, Clemson, SC 29634

. Geographically, Clemson is situated in the northwest corner of South Carolina near the Georgia border, approximately midway between Charlotte, North Carolina, and Atlanta, Georgia—about a two-and-a-half-hour drive from each city. The campus lies adjacent to the city of Clemson, which is in Pickens and Anderson counties

. The university is well integrated into the city and is known for its scenic location near natural features such as Lake Hartwell and the South Carolina Botanical Garden, which is part of the campus

. Clemson University was founded on land that was formerly the Fort Hill Plantation, the estate of U.S. Vice President John C. Calhoun, later willed to the state by Thomas Green Clemson for the establishment of the university