DePaul University is located in Chicago, Illinois, United States. It has two main campuses:

• Lincoln Park Campus: This is the older and larger campus, situated in the Lincoln Park neighborhood of Chicago. It covers about 36 acres and offers a traditional university environment with residence halls and academic buildings

• Loop Campus: Located in downtown Chicago's Loop area along Jackson Boulevard, this campus is close to the financial district and cultural institutions like the Art Institute of Chicago. It houses the Driehaus College of Business, College of Law, College of Computing and Digital Media, and other academic units

The university's primary addresses include 1 East Jackson Boulevard for the Loop campus and 2250 N. Sheffield Ave. for the Lincoln Park campus

. Both campuses are centrally located in Chicago, providing students with access to public transportation and numerous internship and job opportunities