Eliquis (apixaban) is manufactured primarily by Bristol-Myers Squibb at production facilities in Humacao, Puerto Rico, which is a U.S. territory. Additionally, there has been manufacturing of active pharmaceutical ingredients for Eliquis at a facility in Swords, Ireland, which was operated by Bristol-Myers Squibb and recently sold to SK Biotek, a Korean biotech company that continues production there. Manufacturing centers thus include Puerto Rico and historically Ireland, with SK Biotek now involved in Ireland for API production.