The wire set is located in Baltimore, Maryland. The series was filmed on location in various neighborhoods of Baltimore, including West Baltimore, McCulloh Homes, North Avenue, and other real locations in the city that were part of the storyline. Notable filming spots include Lexington Street, Fulton Street, and McCulloh Homes, which served as the backdrop for many scenes in the show. These locations remain recognizable and are part of the show's authentic urban setting.