Frances Tiafoe's parents, Constant (also known as Frances Sr.) Tiafoe and Alphina Kamara, are immigrants from Sierra Leone. They fled the civil war in Sierra Leone and immigrated to the United States in the 1990s—Constant in 1993 and Alphina in 1996

. They settled in Maryland, where Constant worked as a construction worker and later as the head of maintenance and custodian at the Junior Tennis Champions Center in College Park, Maryland, while Alphina worked as a nurse

. This background and environment played a crucial role in Frances and his twin brother Franklin's early exposure to tennis