Tylenol is manufactured by Kenvue, an American consumer health enterprise that was formerly part of Johnson & Johnson. One of the major production sites for Tylenol is in Fort Washington, Pennsylvania. Kenvue, which owns the Tylenol brand, recently established its global headquarters in Summit, New Jersey. The drug is produced in several facilities worldwide, but the Fort Washington site is a significant location for its manufacture.

Additionally, the active ingredient in Tylenol, acetaminophen (also known as paracetamol), has traditionally been made from chemicals derived from crude oil. However, recent advances have introduced production methods using raw materials like wood from palm and poplar trees to make acetaminophen in more environmentally friendly ways.