Tirzepatide is injected subcutaneously (under the skin) into one of three primary sites:

• Abdomen (stomach): Inject at least 2 inches away from the navel to avoid sensitive areas. Rotate injection spots within this area to prevent tissue damage.

• Thigh: The front and outer parts of the thigh are suitable. Avoid inner thigh and areas near the knee. Rotate injection sites within this area as well.

• Upper arm: The back or lower part of the upper arm can be used, though assistance may be needed for proper injection. The injection should go into the fatty tissue, not the muscle.

It is important to rotate injection sites among these areas with each weekly dose to reduce skin irritation, prevent infection, promote optimal absorption, and avoid lumps or scarring.

The injection is done at a 90-degree angle into the pinched skin fold after cleaning the site with an alcohol swab.

In summary, tirzepatide can be safely injected into the abdomen, thigh, or upper arm subcutaneously, with site rotation recommended for best results and comfort.