Zepbound (tirzepatide) should be injected subcutaneously (under the skin) into the fatty tissue of one of the following three sites:

• Stomach: At least 2 inches away from the belly button. Avoid the waistline and hip bone areas.
• Thigh: The outer side of the upper thigh. Avoid the inner thigh.
• Upper arm: The back of the upper arm, about 3 inches below the shoulder and above the elbow. This site is easier for someone else to inject rather than self-injection.

There is no significant difference in absorption among these sites, so choose the most comfortable location. It's important to rotate injection sites with each dose to minimize site reactions, using different spots within the chosen area. These recommendations ensure proper subcutaneous injection and comfortable, effective medication delivery for Zepbound.