The San Francisco 49ers vs. Arizona Cardinals game on Sunday, September 21, 2025, at 4:25 p.m. ET can be watched live on Fox TV. It is also available for streaming on FOXSports.com and the Fox Sports app. Additionally, the game can be streamed on NFL+ (the NFL's official streaming service) and on fubo+.

For fans looking for alternative viewing options, there are live stream watch parties and free streams available on YouTube through channels like the 49ers Report.

To summarize viewing options:

Platform| Details
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Fox TV| Local broadcast for the game
FOXSports.com/App| Live stream available
NFL+| Official NFL streaming service
fubo+| Streaming subscription service
YouTube| Live stream watch parties

This range of options makes the game accessible to fans through traditional TV and multiple streaming services.