The Arizona Cardinals vs. San Francisco 49ers game on Sunday, September 21, 2025, was broadcast on Fox and streamed live on NFL+.

Additional viewing options for fans included the CBS Sports app, and online watch parties such as those on the 49ers Report YouTube channel.

For live streaming, NFL+ is the official platform to watch this game, though some regional restrictions may apply on other platforms like Amazon Prime Video.

In summary, the main way to watch this game live was on the Fox TV channel and the NFL+ streaming service.