Dexter: New Blood was primarily filmed in Western Massachusetts, though the series is set in the fictional town of Iron Lake, New York. The main filming locations include:

• Shelburne Falls, Massachusetts: This historic village served as the stand-in for the fictional Iron Lake. Key town locations like the tavern, grocery store, and town hall were shot here. The iconic Truss Bridge connecting Shelburne and Buckland was featured prominently.

• Dexter's cabin was built at Camp Collier on the shores of Lake Wampanoag near Gardner, Massachusetts. This cabin was constructed specifically for the series and removed after filming.

• Some interior scenes, such as the tavern's inside, were filmed at the Bull Run Restaurant in Shirley, Massachusetts, outside Shelburne Falls.

• Additional filming took place in other Massachusetts towns including Worcester, Holden, Lancaster, and Bolton. For example, school scenes were filmed at Nashoba Regional High School in Bolton.

• Some scenes involving an old mine were filmed at Tantiusques Reservation in Sturbridge, Massachusetts, which features historic mines.

• Filming took place across several counties in Massachusetts, including Franklin County, Worcester County, and Middlesex County. Studios in Devens, Massachusetts were also used.

Overall, the production used a variety of authentic small-town and natural settings in Massachusetts to bring the fictional Iron Lake to life, creating a moody, cold atmosphere very different from the original Miami setting.