Murphy's Romance (1985) was filmed primarily in southern Arizona, with multiple locations used around Florence and nearby towns. Direct answer

• Florence, Arizona: Used for both setting and exterior filming, including locations along Main Street and the Keating Building area (often cited as the town’s core filming backdrop).

• Tubac, Arizona: Exterior scene locations were utilized here, contributing to the film’s Southwestern town atmosphere.

• Tucson, Arizona: Street scenes were shot in and around Tucson, incorporating urban exteriors used in the film.

• Eloy, Arizona: Additional filming sites in the region were used to expand the rural and desert landscapes visible in the movie.

Additional context

• Some interior shots and specific local landmarks used as stand-ins for fictional Eunice, Arizona, were photographed across Florence and nearby communities, with period-accurate sets and exterior façades selected to evoke small-town life in the 1950s–60s American Southwest.

• For interested visitors, Florence’s historic Main Street and surrounding blocks are frequently highlighted in guides as the most recognizable filming locations from Murphy's Romance, with several exterior scenes and the town’s pharmacy facade serving as notable visual anchors in the film.

If you’d like, I can compile a concise list of exact address-level filming spots in Florence and nearby towns, or provide a brief self-guided walking route to see the publicly identifiable exteriors used in the film.