Direct answer: The reported plane crash occurred near Louisville Muhammad Ali International Airport in Louisville, Kentucky, on November 4, 2025, involving a UPS cargo MD-11F. The aircraft crashed shortly after takeoff, ignited a large fireball, and several fatalities were reported, with ongoing investigations by the NTSB and FAA.

Context and details:

• Location: The crash happened immediately after departure from Louisville Muhammad Ali International Airport, with the aircraft impacting areas near the airport and causing fires at nearby facilities.

• Casualties: Initial reports indicated multiple fatalities and injuries on both the aircraft and ground. By the latest updates, authorities confirmed at least seven deaths with additional injuries on the ground, and search and rescue operations were continuing into the next day.

• Aircraft and flight: The aircraft was a UPS MD-11F en route to Honolulu (Daniel K. Inouye International Airport). It had departed Louisville around the early evening local time and entered an abnormal sequence leading to a crash shortly after takeoff.

• Investigation: The incident is being investigated by the National Transportation Safety Board (NTSB) in coordination with the FAA. Details on the exact cause were not immediately available and were subject to ongoing inquiry.

If you’d like, I can pull the latest official findings from the NTSB and FAA reports and summarize them with timelines, aircraft data, and ground impact details.