Investigators pursuing U.S. Public Health Service (PHS) funding are required to disclose their significant financial interests to their institution no later than the time of applying for funding. Additionally, they must disclose any new significant financial interests within 30 days of discovering or acquiring them and update disclosures at least annually during the course of the award.

Details on Disclosure Requirements

• Disclosure must be made at the time of submitting the application for PHS funding to ensure objectivity and transparency in the research.
• Investigators must also update their disclosures within 30 days of acquiring or discovering a new significant financial interest.
• An annual disclosure update is required during the entire period of the PHS award.
• These requirements apply to all investigators involved in the design, conduct, or reporting of PHS-funded research, including subawardees.

This means the institution receives timely and ongoing information about the financial interests of investigators to manage any potential conflicts of interest effectively.

Thus, the most accurate description is the disclosure is required no later than the time of applying for funding , with ongoing updates as new significant financial interests are identified.