Charlie Sheen revealed publicly in 2015 that he has been HIV-positive since around 2011. He has stated that he is uncertain about how or from whom he contracted the virus. Sheen has admitted to a history of sexual encounters with a large number of partners, including sex workers, but has never disclosed a specific individual as the source of his HIV infection. He has insisted that he has informed every sexual partner after his diagnosis and claims that he has not transmitted the virus to anyone else since then.

Sheen also faced lawsuits from former partners alleging he exposed them to HIV without disclosure, but he denied intentionally putting anyone at risk and maintained that his HIV-positive status was known to those partners.

There is no public confirmation or reliable report identifying the exact person from whom Charlie Sheen contracted HIV.