The Colts’ most recent loss was to the Pittsburgh Steelers, 27-20, in Week 9 (November 2, 2025) at Acrisure Stadium. This game featured six Colts turnovers (three interceptions and three fumbles lost) that massively swung the outcome, despite a strong performance from Colts receivers Michael Pittman Jr. and Alec Pierce who both surpassed 100 yards. The Steelers capitalized on those miscues with multiple scoring drives and defensive/return plays to secure the win.