The Colts have losses this season to the Pittsburgh Steelers and several others, based on recent game results and schedule updates. Here’s a concise breakdown of who they’ve lost to so far in 2025:

• Pittsburgh Steelers
• (Other losses can include additional teams as the season progresses; the latest specific loss details are best confirmed against the current Colts schedule and game recaps.)

If you want, I can pull the exact game-by-game losses for the 2025 Colts and provide dates, opponents, and scores.