The main cast of "Who Framed Roger Rabbit" (1988) includes: Live-action cast:

• Bob Hoskins as Eddie Valiant, a private investigator
• Christopher Lloyd as Judge Doom
• Stubby Kaye as Marvin Acme
• Joanna Cassidy as Dolores
• Alan Tilvern as R.K. Maroon
• Richard LeParmentier as Lt. Santino

Voice cast:

• Charles Fleischer as Roger Rabbit, Benny the Cab, Greasy, and Psycho
• Lou Hirsch as Baby Herman
• Kathleen Turner (uncredited) as Jessica Rabbit's voice

Additional voices include Mel Blanc as Bugs Bunny, Daffy Duck, Porky Pig, Tweety, and Sylvester the Cat; Joe Alaskey as Yosemite Sam; Wayne Allwine as Mickey Mouse; Tony Anselmo as Donald Duck, and more.

This cast combines live actors and voice actors who bring both the human and animated characters to life in this unique film blending live-action and animation.