Canelo Álvarez has lost only twice in his professional boxing career. His two losses came against:

1. Floyd Mayweather Jr. on September 14, 2013, by majority decision in a 12-round fight at the MGM Grand in Las Vegas. This fight cost Canelo his WBC and The Ring super welterweight titles.
2. Dmitry Bivol on May 7, 2022, by unanimous decision in a 12-round fight at the light heavyweight level, where Bivol's technical superiority earned him the win.

Both opponents were undefeated champions at the time they defeated Canelo.