The Sistine Chapel's interior decoration was a collaborative effort by several Renaissance artists, but the most famous painter associated with it is Michelangelo.

• The ceiling of the Sistine Chapel was painted by Michelangelo between 1508 and 1512, commissioned by Pope Julius II. This monumental work includes iconic scenes from the Book of Genesis, such as the famous "Creation of Adam"

• The altar wall features Michelangelo's "The Last Judgment," painted between 1534 and 1541 for Pope Paul III

• The side walls of the chapel were decorated earlier, around 1481–1482, by a team of Florentine Renaissance painters including Sandro Botticelli, Pietro Perugino, Domenico Ghirlandaio, Cosimo Rosselli, and others. They painted frescoes depicting the lives of Moses and Christ, as well as portraits of various popes

In summary, while many artists contributed to the Sistine Chapel's frescoes, Michelangelo is the principal artist who painted the ceiling and the altar wall, which are the chapel's most renowned artworks. Other notable painters involved in decorating the side walls include Botticelli, Perugino, and Ghirlandaio