The main stars of the 2025 film Nonnas include:

• Vince Vaughn as Joe Scaravella, the protagonist who opens an Italian restaurant staffed by grandmothers to honor his late mother.
• Susan Sarandon as Gia, Joe's mother's hairdresser.
• Lorraine Bracco as Roberta, Joe's mother's best friend.
• Talia Shire as Teresa, an applicant for the nonna chef job.
• Brenda Vaccaro as Antonella, Olivia's neighbor and one of the nonnas.
• Linda Cardellini as Olivia, Joe's high school crush and a first-year law student who helps with the restaurant's legal matters.
• Joe Manganiello as Bruno, Joe's best friend.
• Drea de Matteo as Stella, Bruno's wife.
• Michael Rispoli as Al, a Staten Island resident skeptical of Joe's restaurant.
• Campbell Scott as Edward Durant, a food critic.

The film features a notable ensemble of veteran actresses playing the nonnas, including Sarandon, Bracco, Vaccaro, and Shire, who bring to life the grandmothers cooking in the restaurant