The winners of Monday Night Football on September 15, 2025, were the Tampa Bay Buccaneers and the Los Angeles Chargers.

• The Tampa Bay Buccaneers won a dramatic game against the Houston Texans, 20-19. Baker Mayfield led a game-winning 11-play, 80-yard drive culminating in Rachaad White's 2-yard touchdown run with only six seconds left on the clock.

• The Los Angeles Chargers also won their game, defeating the Las Vegas Raiders 20-9. The Chargers showcased a strong defensive performance, and quarterback Justin Herbert threw for 242 yards and two touchdowns.

Thus, both games on Monday Night Football ended in victories for the Buccaneers and the Chargers.