The main reasons for never feeling hungry can include stress, anxiety, depression, illness, medication side effects, hormonal changes, aging, overtraining, and certain medical conditions. Hunger is regulated by the brain, hormones, blood sugar levels, and signals from the stomach and intestines, so disruptions in these areas can reduce or eliminate the sensation of hunger. Lifestyle factors, like eating habits and busy schedules, can also affect hunger signals, and some people simply get used to eating less frequently. If this loss of appetite leads to weight loss or nutritional problems, it might indicate an underlying health issue that warrants medical consultation.