Yes, you can take Mucinex (guaifenesin) and ibuprofen together. There are no known drug interactions between the two, and they can be safely taken at the same time to manage symptoms like pain, fever, cough, and congestion related to respiratory infections. Ibuprofen helps reduce pain and fever, while Mucinex acts as an expectorant to loosen and thin mucus for easier clearing from airways. However, people with underlying health conditions such as kidney, liver, or heart disease, or those who have a risk of bleeding or stomach ulcers, should use ibuprofen with caution and consult a healthcare provider before combining these medications. Also, Mucinex DM contains an additional ingredient, dextromethorphan, which requires caution if taken with certain other medications. In summary, Mucinex and ibuprofen can be used together safely for most people, but individual health status and other medications should be considered, and consulting a healthcare provider is advisable if uncertain.