It is generally considered safe to take certain cold and flu tablets during pregnancy, but it is very important to choose them carefully and consult with a healthcare professional first. Some medications commonly regarded as safe during pregnancy include:

• Acetaminophen (Tylenol) for pain and fever.
• Dextromethorphan (Robitussin) for cough.
• Guaifenesin (plain Mucinex) for chest congestion.
• Certain antihistamines like loratadine (Claritin) or diphenhydramine (Benadryl).
• Mentholated creams like Vicks Vapor Rub.
• Saline nasal sprays and short-term use of nasal decongestant sprays like oxymetazoline (Afrin) for up to 3 days.

Medications to avoid during pregnancy include:

• Combination cold and flu products with multiple ingredients, especially those containing alcohol or certain antihistamines (like Nyquil or Dayquil).
• Oral decongestants such as pseudoephedrine (Sudafed) and phenylephrine.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, aspirin, and naproxen.

Pregnant women are recommended to get the flu vaccine as it is safe and helps prevent complications from flu infection. In all cases, it is best to seek medical advice before taking any cold or flu medication while pregnant, especially in the first trimester, to ensure safety for both mother and baby.

Summary of safe and unsafe cold and flu medications during pregnancy

Medication Type| Safe in Pregnancy| Avoid During Pregnancy
---|---|---
Pain and Fever| Acetaminophen (Tylenol)| NSAIDs (ibuprofen, aspirin, naproxen)
Cough| Dextromethorphan, Guaifenesin| Multi-symptom combo products with alcohol
Nasal Congestion| Saline sprays, short-term oxymetazoline nasal spray| Oral decongestants (pseudoephedrine, phenylephrine)
Antihistamines| Loratadine, Diphenhydramine| Certain combo antihistamines (Nyquil, Dayquil)
Topical| Mentholated creams (Vicks Vapor Rub)| N/A

Always consult a healthcare provider before taking any medication when pregnant.