The main cast of the film "Are You There God? It's Me, Margaret." (2023) includes:

• Abby Ryder Fortson as Margaret Simon (the title character)
• Rachel McAdams as Barbara Simon (Margaret's mother)
• Kathy Bates as Sylvia Simon (Margaret's grandmother)
• Benny Safdie as Herb Simon (Margaret's father)
• Elle Graham as Nancy Wheeler
• Amari Alexis Price as Janie Loomis
• Katherine Kupferer as Gretchen Potter
• Kate MacCluggage as Mrs. Jan Wheeler
• Aidan Wojtak-Hissong as Moose Freed
• Landon S. Baxter as Evan Wheeler
• Echo Kellum as Mr. Benedict (Margaret's teacher)

This coming-of-age comedy-drama was written and directed by Kelly Fremon Craig, based on Judy Blume's 1970 novel of the same name.