Lidocaine generally starts working within minutes, but the exact onset depends on the form used: injections can act in 2 to 5 minutes, sprays in 2-5 minutes, topical creams and gels within 25-60 minutes, and patches typically within about 30 minutes.

Injectable Lidocaine

• When administered by injection, lidocaine's numbing effects begin in about 2 to 5 minutes, reaching full effect often within 4 minutes, and lasting from 30 minutes up to three hours depending on dosage and additives like epinephrine.

Topical Lidocaine (Creams, Gels, Sprays)

• Topical lidocaine (creams/gels/sprays) usually produces a numbing effect within 25-60 minutes, though some products can begin working almost immediately and reach full potency in about 35-40 minutes.

• Lidocaine sprays typically start working within 2–5 minutes, with maximum effect around 4–5 minutes.

Lidocaine Patches

• Lidocaine patches start providing pain relief in as little as 30 minutes but may take up to 4 hours for some individuals to notice benefits, with pain relief lasting 8–12 hours.

Summary Table

Formulation| Time to Start Working
---|---
Injection| 2–5 minutes 89
Spray| 2–5 minutes 2
Cream/Gel| 25–60 minutes 356
Patch| 30 min–4 hours 1

Lidocaine is considered fast-acting, but always refer to product instructions and consult a healthcare provider for precise recommendations on use and timing.