Jimmy Kimmel's late-night talk show, "Jimmy Kimmel Live!," has been on air since January 26, 2003. It is an hour-long show that originally aired at 12:05 a.m. ET/PT for its first ten years before moving to the 11:35 p.m. time slot in 2013. The show has been the longest-running late-night talk show on ABC and the second-longest running by host on any network, behind only Johnny Carson's tenure on "The Tonight Show".

However, as of September 17, 2025, the show was indefinitely suspended by ABC following controversial remarks made by Jimmy Kimmel regarding the reaction of the MAGA movement to the assassination of Charlie Kirk. This suspension means no new episodes are currently airing.

So, "Jimmy Kimmel Live!" had been on air continually for over 22 years until its recent suspension in September 2025, with a typical runtime of about one hour per episode.