The term appears to refer to nitazenes, a class of extremely potent synthetic opioids that have emerged in recent years as a dangerous overdose risk. What nitazeni are

• Nitazenes are synthetic opioids with analgesic potency far greater than morphine and often stated to be many times stronger than fentanyl. They were originally developed in the mid-20th century but were never marketed due to safety concerns, and have resurfaced in the illicit drug supply in various regions since around 2019–2020. They can be found in forms such as liquids, pills, or powders and may cause fatal overdoses even in very small quantities. [nitazeni](javascript:void(0)) [serve](javascript:void(0)) [cosa](javascript:void(0)) [serve](javascript:void(0)) [nitazeni](javascript:void(0))

Why they are dangerous

• Their high potency makes overdose risk much higher than more common opioids, and standard overdose interventions may be less reliable. Some nitazene compounds may not be detected by routine drug screening, complicating medical response and public health monitoring. naloxone can reverse many opioid overdoses but may be less effective against certain nitazenes, requiring higher or multiple doses and advanced medical care.

Current status and implications

• Reports and investigations from Europe, North and South America, and parts of Asia indicate ongoing presence and risk, with Italy (and other countries) documenting local overdose cases linked to nitazenes. Public health responses emphasize expanded testing, public awareness, harm reduction, and readiness of emergency services to manage overdoses with higher-than-usual opioid potency.

What to do if concerned

• If there is any suspicion of exposure or overdose, seek emergency medical help immediately. If trained, administer naloxone according to local guidelines and monitor the person until professional medical assistance arrives, recognizing that response times and effectiveness can vary with nitazenes. Public health guidance stresses avoiding use of unknown substances, using only tested and sourced products, and engaging with harm-reduction resources where available.

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