The "Seven Sisters" most famously refers to the Pleiades, a cluster of stars in the constellation Taurus. In Greek mythology, the Seven Sisters were the daughters of Atlas and Pleione, transformed by Zeus into stars to protect them from the hunter Orion. Their names are Maia, Alcyone, Asterope, Celaeno, Taygete, Electra, and Merope. The Pleiades symbolize sisterhood linked with themes of protection and celestial beauty, and the cluster is sometimes called the "Seven Stars" or "Seven Doves," representing their transformation in the mythological tale.

In other cultural contexts, such as Australian Aboriginal mythology, the Seven Sisters story represents perseverance and transformation. The sisters undergo difficult trials, eventually ascending to the sky as a star cluster symbolizing endurance and moral lessons maintained through generations.

Additionally, the term "Seven Sisters" has been used in modern contexts for prestigious groups such as seven historic women's colleges in the U.S., and for groups of companies or geographical features, but its primary and classical meaning is rooted in the mythological and astronomical constellation of the Pleiades.

Thus, "Seven Sisters" meaning is most commonly associated with the mythological and celestial Pleiades cluster, symbolizing sisterhood, protection, and transformation across many cultures.