Lupe Samano appeared on Season 3 of "My 600-Lb Life" and was bedridden due to her weight and food addiction. She was completely dependent on her then-husband, Gilbert, and was unable to do anything. Lupe eventually lost enough weight to qualify for surgery and underwent gastric bypass surgery. She lost over 400 pounds and got down to nearly 200 pounds. She had skin removal surgery, which also helped her to drop some pounds. Lupe appeared in two "My 600-Lb. Life: Where Are They Now?" episodes, which aired in 2017 and 2018. She worked hard to lose even more weight so that she could get hip replacement surgery. Lupe has not updated her public social media since 2019, but her latest posts reveal that she was able to keep the weight off. Lupe revealed that she had broken up with her ex-husband, Gilbert, and is now living in San Antonio. She continued her weight loss journey and listed her hobbies as open-water swimming, shopping, volunteering, visiting theme parks, relaxing, and portrait photography. As of 2019, Lupe was down to about 220 lbs, but it is unclear how much she weighs now as she values her privacy and her social media profiles are locked down.