Nick Bosa, the Pro Bowl edge rusher for the San Francisco 49ers, suffered a torn ACL in his right knee during a game against the Arizona Cardinals on Sunday, September 21, 2025. This injury is to the same knee he previously injured in 2020. Following an MRI on Monday, it was confirmed that Bosa will require season-ending surgery and will miss the remainder of the 2025 NFL season. He left the game late in the first quarter after recording two tackles and forcing a fumble, signaling a thumbs-down as he exited the field. The 49ers now face the challenge of filling the void left by his absence in their defense.

Bosa has been a key player for the 49ers since being drafted in 2019, earning multiple Pro Bowl selections, including the AP Defensive Player of the Year in 2022. His injury is a significant setback for the team, which already has other players sidelined with injuries.